What is CIMED?
CIMED is an in vitro diagnostic platform designed for clinical and research use in complement-mediated disease monitoring. Developed by Compvide, it consists of three pathway-specific functional ELISA kits — CIMED-AP (Alternative Pathway), CIMED-CP (Classical Pathway), and CIMED-LP (Lectin Pathway) — designed for complement activity measurement, inhibition profiling, and pharmacodynamic drug monitoring in clinical trials.
Unlike conventional complement assays, CIMED kits are engineered to deliver clean, pathway-isolated data under physiologic, high-serum conditions — directly relevant to drug development and therapeutic monitoring.
CIMED products are for in vitro research use only. Not approved for diagnostic or clinical use.
Why CIMED?
Built from the ground up for complement-targeted drug development.
Pathway-Specific
Each kit isolates a single complement pathway, eliminating crosstalk for clean, interpretable data.
Functional ELISA Format
Measures actual pathway activity, not just protein levels. Provides physiologically relevant results.
Drug Monitoring Ready
Purpose-built for pharmacodynamic assessment of complement-targeted therapeutics in clinical trials.
Research Use Only
Currently designated RUO. Developed under rigorous quality standards for translational and clinical research.
CIMED Product Suite
Three pathway-specific platforms covering the functional complement system.
CIMED-APTM
Alternative Pathway Activity & Drug Monitoring
Measures physiologic alternative pathway activity, amplification loop competence, and therapeutic drug effects under high-serum conditions.
- PNH, aHUS, gMG, NMOSD, C3G, IC-MPGN
- Complement drug development & mechanistic profiling
- Alternative pathway inhibitor monitoring
- Evaluation of off-target complement effects
CIMED-CPTM
Classical Pathway Immune Complex Activity
Measures immune-complex–driven classical pathway activation under physiologic serum conditions for mechanistic autoimmune profiling.
- CAD, SLE, vasculitis, immune-complex diseases
- Complement drug development & profiling
- Classical pathway inhibitor monitoring
- Biologic & immunotherapy safety assessment
CIMED-LPTM
Lectin Pathway Innate Immune Activation
Quantifies lectin-mediated complement activation for innate immune phenotyping and infection-related risk assessment.
- HSCT-TMA & innate immune profiling
- Infection susceptibility studies
- Translational research applications
- Lectin pathway inhibitor monitoring & safety surveillance
Product Specifications
Technical specifications for the CIMED complement diagnostic platform.
| Specification | CIMED-AP™ | CIMED-CP™ | CIMED-LP™ |
|---|---|---|---|
| Complement Pathway | Alternative | Classical | Lectin |
| Assay Format | Functional ELISA | Functional ELISA | Functional ELISA |
| Sample Type | Human serum, plasma | Human serum, plasma | Human serum, plasma |
| Application | Activity measurement, drug monitoring, inhibition profiling | Activity measurement, drug monitoring, inhibition profiling | Activity measurement, drug monitoring, inhibition profiling |
| Regulatory Status | Research Use Only | Research Use Only | Research Use Only |
| Manufacturer | Compvide | Compvide | Compvide |
Applications
CIMED kits are designed to support a range of use cases across the complement therapeutics pipeline.
Pharmacodynamic (PD) drug monitoring in clinical trials
Complement pathway-specific inhibition profiling
Preclinical and translational research studies
Biomarker program development and validation
Clinical study sample analysis (serum/plasma)
Drug potency and mechanism-of-action studies